{"id":45333,"date":"2018-11-15T12:20:31","date_gmt":"2018-11-15T12:20:31","guid":{"rendered":"https:\/\/shawellness.com\/shamagazine\/en\/?p=45333"},"modified":"2022-03-04T08:55:27","modified_gmt":"2022-03-04T08:55:27","slug":"obesity-and-inflammation","status":"publish","type":"post","link":"https:\/\/shawellness.com\/shamagazine\/en\/obesity-and-inflammation\/","title":{"rendered":"Obesity and Inflammation"},"content":{"rendered":"<p><strong>Obesity is an excessive accumulation of fat that can affect the optimum state of health<\/strong>. It is common knowledge that <strong>the excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators<\/strong> and <strong>decrease the secretion of inflammation inhibitors<\/strong>, thus<strong> creating a pro-inflammatory<\/strong> and <strong>oxidative stress environment<\/strong>.<\/p>\n<p><strong>Obesity is one of the characteristic elements of the metabolic syndrome<\/strong>. It <strong>appears<\/strong> that the <strong>relationship between these two factors<\/strong> is<strong> established through inflammation<\/strong>.<\/p>\n<p>There are <strong>two types of adipose tissues<\/strong>: <strong>brown<\/strong> and <strong>white<\/strong>. In new-borns, the brown adipose tissue helps regulate the energy used by means of thermogenesis. <strong>In adults<\/strong>, there is an <strong>inverse correlation between the brown adipose tissue and the body mass index<\/strong> (BMI). That is to say, the<strong> higher the BMI<\/strong>, the<strong> smaller the amount of brown adipose tissue<\/strong>. This is especially common in seniors, which highlights the role of this tissue in the human metabolism. The <strong>white adipose tissu<\/strong>e was thought to be a type of inert tissue, whose only function was to store energy. Now we know that is has a much more important role and that it is <strong>actively involved in regulating both physiological<\/strong> and p<strong>athological processes<\/strong>, <strong>including immunity<\/strong> and <strong>inflammation<\/strong>.<\/p>\n<p><strong>Inflammation is an ordered sequence of events<\/strong> that <strong>consist in the release of mediators<\/strong> and the <strong>expression of chemical receptors in our body<\/strong>, this is intended to maintain the homeostasis of the organs and the tissues and it is <strong>also a response mechanism to the damag<\/strong>e and <strong>destruction of the tissues<\/strong>.<\/p>\n<p>There are <strong>two types of inflammation depending on how long it lasts<\/strong>: <strong>acute<\/strong> and <strong>chronic<\/strong>. The differences between these two types are:<\/p>\n<ul>\n<li><strong>Acute inflammation is short-term<\/strong> and at<strong> a cellular level it is characterised by oedema<\/strong> and leukocyte proliferation.<\/li>\n<li><strong>Chronic inflammation lasts longer<\/strong> and <strong>it results in connective tissue<\/strong> and <strong>blood vessel proliferation phenomena<\/strong>, along with the<strong> migration of other cells of the immune system<\/strong>: the lymphocytes and the macrophages.<\/li>\n<\/ul>\n<p><strong>These inflammatory phenomena are mediated by numerous different molecules<\/strong>, such as the Interleukin <strong>-6 (IL-6)<\/strong>, the tumour necrosis factor -\u03b1 (TNF-\u03b1), or the C-reactive protein (CRP).<\/p>\n<p><strong>Obesity has been widely associated with chronic inflammation<\/strong>, which is a <strong>cardiovascular risk factor<\/strong> and it is the leading cause of other diseases such as bleeding disorders, arteriosclerosis, insulin resistance and diabetes.<\/p>\n<p><strong>When there are excess nutrients more adipose cells are produced<\/strong> (hyperplasia), <strong>which are bigger<\/strong> (hypertrophy). <strong>This increases the possibilities of the blood vessels<\/strong> <strong>not supplying the adipose tissue with enough oxygen<\/strong> (hypoxia). This <strong>produces changes in the tissue<\/strong>, such as <strong>cell death<\/strong> (necrosis), which is interpreted as being a type of damage that leads to the secretion of the aforementioned pro-inflammatory substances, along with free radicals.<\/p>\n<p><strong>Numerous studies describe a positive relationship between the levels of obesity and IL-6<\/strong>. In fact, one third of the IL-6 concentrations found in our blood come from the adipose tissue.<strong> Another marker that is often associated with obesity is the C-reactive protein<\/strong>, which increases when the body mass index increases.<\/p>\n<p><strong>High levels of CRP are associated with myocardial infarction<\/strong>, high blood pressure, <strong>cardiovascular events in diabetics<\/strong> and strokes. The <strong>CRP is synthesized in the liver<\/strong> and this <strong>synthesis is mediated by IL-6.<\/strong><\/p>\n<p><strong>This overexpression of pro-inflammatory substances<\/strong> is c<strong>onsidered to be the connecting link between obesity and inflammation<\/strong>. The <strong>increase in pro-inflammatory mediators<\/strong> is <strong>related to cardiometabolic risk<\/strong>, arteriosclerosis, <strong>coronary heart disease<\/strong> and heart failure.<\/p>\n<p>The <strong>adiponectin is a substance that has an anti-inflammatory and anti-atherogenic effect<\/strong>. It is <strong>produced by the adipocytes<\/strong>. However, less of this is released when there is more adipose tissue. The <strong>high levels of CRP<\/strong>, <strong>IL-6 and free radicals are associated with a decrease in the adiponectin<\/strong>. In fact, t<strong>he administration of antioxidant agents re-establishes the production of adiponectin<\/strong>, which<strong> provides protection against vascular endothelium damage caused by oxidative stress<\/strong>.<\/p>\n<p>It<strong> has been proved that calorie restriction<\/strong> and the <strong>subsequent weight loss reduce the levels of these pro-inflammatory markers<\/strong>.<strong> With regard to the type of die<\/strong>t, it<strong> has been demonstrated that those with high sugar<\/strong> content <strong>increase these markers of systemic inflammation<\/strong>. In one study carried out on healthy adults who consumed food products that were high in glucose or fructose for two weeks, an increase in the CRP was observed. The<strong> trans fats in the diet also increase the levels of pro-inflammatory substances<\/strong>. In contrast to this, it has been observed that in <strong>high fibre diets<\/strong>,<strong> whether it is in the diet itself or as a supplement<\/strong>, there is a <strong>decrease in the levels of PCR and IL-6<\/strong>.<\/p>\n<p>All this data goes to show that an <strong>excess in weight is the equivalent of a pro-inflammatory condition that causes oxidative stress and damages the endothelium of our arteries,<\/strong> but we can r<strong>everse this condition through a diet that restores our ideal weight<\/strong>, which is also <strong>rich in antioxidant<\/strong> and <strong>anti-inflammatory agents<\/strong>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Obesity is an excessive accumulation of fat that can affect the optimum state of health. It is common knowledge that the excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators and decrease the secretion of inflammation inhibitors, thus creating a pro-inflammatory and oxidative stress environment. Obesity is one of the characteristic [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":45347,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-formats\/single-template-expert.php","format":"standard","meta":{"_acf_changed":false,"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[32],"tags":[],"class_list":["post-45333","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health-beauty"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Obesity and Inflammation | SHA Magazine<\/title>\n<meta name=\"description\" content=\"The Coordinator of Medical Services &amp; Natural Therapies, Carlos Guti\u00e9rrez, explains the relation between obesity and inflammation.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/shawellness.com\/shamagazine\/en\/obesity-and-inflammation\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Obesity and Inflammation | SHA Magazine\" \/>\n<meta property=\"og:description\" content=\"The Coordinator of Medical Services &amp; 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