{"id":72777,"date":"2021-01-14T14:41:56","date_gmt":"2021-01-14T12:41:56","guid":{"rendered":"https:\/\/shawellness.com\/shamagazine\/tabaquismo-genoma-y-factores-ambientales\/"},"modified":"2022-11-09T20:37:56","modified_gmt":"2022-11-09T18:37:56","slug":"tabaquismo-genoma-y-factores-ambientales","status":"publish","type":"post","link":"https:\/\/shawellness.com\/shamagazine\/es\/tabaquismo-genoma-y-factores-ambientales\/","title":{"rendered":"Tabaquismo, genoma y factores ambientales"},"content":{"rendered":"

\u00bfPor qu\u00e9 algunas personas fuman y otras no? Estudios de familias que incluyen gemelos id\u00e9nticos, mellizos, ni\u00f1os adoptados y hermanos sugieren que hasta el 50 por ciento del riesgo que tiene una persona de volverse adicta a la nicotina depende de su composici\u00f3n gen\u00e9tica.<\/p>\n

Por ejemplo, el riesgo de sufrir un trastorno por fumar cannabis tiene un fuerte componente gen\u00e9tico. En un trabajo cient\u00edfico<\/a> publicado en la revista Nature Neuroscience se determin\u00f3 que bajos niveles de expresi\u00f3n del gen CHRNA2 en el cerebelo estaban asociados con el trastorno por el consumo de cannabis, incluido el diagn\u00f3stico a una edad m\u00e1s temprana. Adem\u00e1s, se hall\u00f3 que los factores gen\u00e9ticos asociados con logros educativos actuaban como protectores contra el trastorno.<\/p>\n

Los hallazgos sugieren que la subexpresi\u00f3n de CHRNA2 en el cerebelo (y probablemente en otras \u00e1reas del cerebro) participar\u00eda en trastornos como el consumo de cannabis y ofrece un blanco potencial para las estrategias de prevenci\u00f3n, los tratamientos y los medicamentos futuros.<\/p>\n

<\/strong><\/p>\n

Factores ambientales y entorno<\/strong><\/p>\n

Sin embargo, el rol de los factores ambientales en la adicci\u00f3n a la nicotina (y otras drogas) tambi\u00e9n es muy importante. Las investigaciones demuestran que la adicci\u00f3n de una persona es el resultado de interacciones din\u00e1micas entre sus genes y el medio en que vive.<\/p>\n

Por ejemplo, se ha visto que una comunidad que ofrece actividades saludables despu\u00e9s de clase reduce la vulnerabilidad a la adicci\u00f3n al tabaco (y otras drogas) y los datos indican que el acceso a la actividad f\u00edsica puede desalentar el comportamiento de b\u00fasqueda de drogas, un efecto que es m\u00e1s pronunciado en los hombres que en las mujeres.<\/p>\n

Los estudios sugieren que el consumo de drogas de un animal puede verse afectado por el consumo que hace su compa\u00f1ero de jaula, lo que indicar\u00eda que algunas influencias sociales pueden aumentar el riesgo o la protecci\u00f3n.<\/p>\n

Adem\u00e1s, es obvio la exposici\u00f3n a las drogas o al estr\u00e9s en el entorno social o cultural de una persona puede alterar tanto la expresi\u00f3n como la funci\u00f3n de los genes, lo que en algunos casos puede persistir durante toda la vida.<\/p>\n

Las investigaciones tambi\u00e9n sugieren que los genes pueden influir en la forma en que las personas responden a su entorno, lo que colocar\u00eda a algunas de ellas en mayor riesgo de contraer enfermedades.<\/p>\n

 <\/p>\n

La gen\u00e9tica y las posibilidades que ofrece la farmacogen\u00f3mica<\/strong><\/p>\n

Un grupo internacional de m\u00e1s de 100 cient\u00edficos utiliz\u00f3 una extensa base de datos para recolectar informaci\u00f3n sobre los comportamientos relacionados con el consumo de tabaco y alcohol. Midieron conductas como, por ejemplo, la edad en que comenzaron a fumar y la edad en que dejaron, la cantidad de cigarrillos diarios y la cantidad de bebidas semanales. Luego establecieron referencias cruzadas entre esos hallazgos y los sucesos de la vida (como los a\u00f1os de estudio), las caracter\u00edsticas f\u00edsicas (como la frecuencia card\u00edaca y el nivel de colesterol) y las enfermedades sufridas (como trastornos de salud mental o diabetes tipo 2). Los investigadores correlacionaron esos resultados con genes espec\u00edficos que se sospechaban en varios tipos de consumo de drogas.<\/p>\n

As\u00ed, descubrieron que hab\u00eda m\u00e1s de 400 ubicaciones en el genoma y al menos 566 variantes entre estas ubicaciones que influyen en el consumo de drogas y alcohol, lo que aproxima a la ciencia a identificar conglomerados de genes que podr\u00edan participar en la adicci\u00f3n.<\/p>\n

El estudio incluso identific\u00f3 nuevos genes y funciones que no se esperaba que cumplieran una funci\u00f3n importante en la adicci\u00f3n. Tres de las ubicaciones gen\u00e9ticas (identificadas como CUL3, PDE4B, PTGER3) se conectaban con todos los fenotipos de consumo de tabaco y alcohol que se midieron.<\/p>\n

Los genes influyen en la cantidad y el tipo de receptores del cerebro de una persona, la rapidez con que el organismo metaboliza las drogas y la forma en que responde a distintos medicamentos. Conocer m\u00e1s sobre las bases gen\u00e9ticas, epigen\u00e9ticas y neurobiol\u00f3gicas de la adicci\u00f3n permitir\u00e1 el avance de la ciencia en el estudio de la adicci\u00f3n.<\/p>\n

Pronto se podr\u00e1 aplicar este conocimiento en tratamientos nuevos dirigidos a blancos espec\u00edficos en el cerebro o a estrategias de tratamiento, lo que se denomina como farmacogen\u00f3mica. Esta ciencia emergente promete aprovechar el poder de la informaci\u00f3n gen\u00f3mica para mejorar los tratamientos para la adicci\u00f3n adaptando el tratamiento a la composici\u00f3n gen\u00e9tica espec\u00edfica de una persona.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u00bfPor qu\u00e9 algunas personas fuman y otras no? Estudios de familias que incluyen gemelos id\u00e9nticos, mellizos, ni\u00f1os adoptados y hermanos sugieren que hasta el 50 por ciento del riesgo que tiene una persona de volverse adicta a la nicotina depende de su composici\u00f3n gen\u00e9tica. Por ejemplo, el riesgo de sufrir un trastorno por fumar cannabis […]<\/p>\n","protected":false},"author":8,"featured_media":75399,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"single-formats\/single-template-expert.php","format":"standard","meta":{"_acf_changed":false,"_sitemap_exclude":false,"_sitemap_priority":"","_sitemap_frequency":"","footnotes":""},"categories":[1411],"tags":[],"class_list":["post-72777","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-sha-magazine"],"acf":[],"yoast_head":"\nTabaquismo, genoma y factores ambientales - SHA Magazine<\/title>\n<meta name=\"description\" content=\"\u00bfPor qu\u00e9 algunas personas fuman y otras no? 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